Using lasers for excitation (opposed to a filtered broad-spectrum light source) the LSM-510META is capable of single and multifluorophore acquisition in the X, Y, and Z direction. An optional adjustable heated stage allows for imaging of living samples. Through the use of independently adjustable pinholes, this microscope allows for the imaging of a specimen in a single plane of focus producing a sharper image.
The laboratory workhorse, the Axioplan is capable of bright-field, DIC, and fluorescence imaging of a variety of fixed samples. A color CCD allows for full-color brightfield image capture, and a high resolution monochromatic CCD provides for high quality, low noise fluorescence image capture.
Similar to the axioplan in features, this inverted scope also has the capability of imaging glass and plastic bottomed cell culture flasks and plates. The axiovert is capable of bright-field, DIC, and fluorescent imaging of a variety of fixed samples. A color CCD allows for full-color brightfield image capture. A high resolution monochromatic CCD provides high quality fluorescent image capture. The Axiovert is also equipped with a monochrome Solamere CCD for high speed live cell imaging.
The Olympus SZX12 is a general purpose dissection microscope with brightfield, darkfield, and fluorescence capabilities. Low magnification objectives allow for imaging of large samples including whole tissues and embryos. High magnification objectives allow for more detailed imaging of samples not suited for traditional slide-based microscopy.
The Hitachi H-7600 Transmission Electron Microscope is a very user-friendly, mostly automated microscope. It requires only minimal user training to get started and is very easy to use. It has both high-resolution and high-magnificaiton capabilities, and can image on both film as well as a Kodak 2Kx2K digital camera.
Working from the same platform as the Axiovert, The T.I.R.F. microscope is capable of handling both regular fluorescent imaging (using a variety of filter cubes and a broad spectrum light source) and total internal reflectance imaging using an Argon 488 laser. T.I.R.F. microscopy allows the user more precise acquisition of dynamic events occurring within 120nm of the coverslip, making this system ideal for imaging membrane trafficking in living systems.
Using lasers for excitation (opposed to a filtered broad-spectrum light source) the LSM-710 is capable of single and multifluorophore acquisition in the X, Y, and Z direction. An optional adjustable heated stage and environmental chamber allows for imaging of living samples. Through the use of independently adjustable pinholes, this microscope allows for the imaging of a specimen in a single plane of focus producing a sharper image.
Olympus FV1000 Confocal
The Olympus system uses laser excitation to aid in the acquisition of single and multiple fluorophore signals in the X, Y, and Z direction. An optional environmental chamber insert allows for live cell imaging. This system is equipped with 405, 458/479/514, 559, 635 nm lasers and is capable of magnifications between 10x and 60x.
Molecular Devices offers fully integrated solutions to assist with high content cellular imaging and analysis in order to efficiently obtain the most significant conclusions through the highest quality of data. From in-depth analysis in research to rapid selection of ‘hits’ in high-throughput screening laboratories, these high content screening systems eliminate manual data manipulation and transfer, which produces rapid, high quality images and increases productivity.
The DeltaVision OMX-SR microscopy system is capable of high speed 2D and 3D Structured Illumination Microscopy (SIM), Ring-TIRF, widefield, and Localization Microscopy resulting in images with greater resolution than those available with standard microscopy systems. The laser module includes 405, 488, 568, and 640nm wavelengths, which work well with most standard fluorphores used in scientific investigation. Rapid image acquisition is performed using a 60X 1.42NA objective and a dual CMOS camera setup, and environmental temperature control allows the system to image living cells in addition to classically prepared fixed samples. Single molecule localization microscopy increases image resolution even further, but requires using photoactivatable or photoswitchable fluorophores and a more stringent preparation protocol.